College football fans will be treated to several star-studded showdowns on Saturday, including No. 1 Ohio State vs. No. 17 Illinois, No. 7 Indiana vs. No. 3 Oregon and No. 6 Oklahoma vs. Texas. The Oregon vs. Indiana matchup features two undefeated Big Ten teams with championship aspirations. According to the latest Week 7 college football odds, the Ducks are favored by 7 points at home, while the over/under for total points scored is 53.5. SportsLine’s model is backing Oregon, which has won 18 consecutive games at home, to cover the spread in 58% of simulations. 

The model is also backing Georgia (-4) to cover the spread at Auburn, while the Over (56.5) hits 60% of the time in Michigan vs. USC. Before locking in your Week 7 college football picks, be sure to check out the top college football betting picks from SportsLine’s advanced computer model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns, and new users can also target the BetMGM bonus code, which offers up to $1,500 in bonus bets if your first bet loses:

Week 7 college football best bets for Saturday, Oct. 11 (odds subject to change): 

• Oregon (-7) vs. Indiana
• Georgia (-4) vs. Auburn
• Over 56.5 points in Michigan vs. USC

Combining the model’s three picks into a Week 7 college football parlay would result in a payout of +612 (risk $100 to win $612). Bet it now at Caesars Sportsbook: 

Oregon -7 vs. Indiana

Oregon is 18-0 in its last 18 games played at home, and the Ducks are 16-1 in their past 17 games against an opponent from the Big Ten. Indiana features the nation’s third-ranked scoring defense, giving up 9.60 points per game this season, but the Hoosiers have yet to face an offense as explosive as Oregon’s. The Ducks are scoring 46.6 points per game, and quarterback Dante Moore is a Heisman Trophy candidate with 1,210 passing yards, 14 touchdowns and just one interception. The model is projecting Oregon to cover the spread in 58% of simulations, providing clear value on the spread. 

Georgia -4 vs. Auburn

Georgia has dominated this rivalry in recent years, winning eight straight against the Tigers. The Bulldogs are 18-2 in their past 20 games on the road and are 9-3 against the spread in their last 12 meetings against Auburn. SportsLine’s model is backing Georgia to cover the spread in 62% of simulations, targeting the Bulldogs as one of its top Week 7 college football picks. 

Over 56.5 points in Michigan vs. USC

Two historic programs are set to collide when USC hosts Michigan at 7:30 p.m. ET. Michigan is coming off a 24-10 win over Wisconsin, while USC suffered a 34-32 setback against Illinois in its last outing. Despite the defeat, the Trojans are averaging 48.4 points per game, which ranks third in the nation. The total has gone Over in seven of USC’s last eight games at home, and SportsLine’s model is projecting these teams will combine for 62 points on Saturday, helping the Over hit in 60% of simulations.

Want more Week 7 college football picks?

You’ve seen the model’s Week 7 college football best bets for Saturday. Now, get against the spread, total and money line picks for every Week 7 CFB game here, all from the model that’s simulated every game 10,000 times.